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Selected animal models for systematic antiatherosclerotic drug development
Advances in Experimental Medicine and Biology
|January 1, 1978
Summary
This study introduces a novel integrated system using animal models to screen antiatherosclerosis drugs. The goal is to improve the success rate of identifying effective treatments for human atherosclerosis.
Area of Science:
- Pharmacology
- Cardiovascular Research
- Drug Development
Background:
- Atherosclerosis is a major human disease requiring effective drug treatments.
- Current drug development pipelines face challenges in identifying successful antiatherosclerosis therapies.
Purpose of the Study:
- To present an integrated drug development system for antiatherosclerosis.
- To enhance the probability of discovering effective antiatherosclerosis drugs for human clinical trials.
Main Methods:
- Utilizing a multi-species animal model system including rats, SEA quail, and cynomolgus monkeys.
- Screening thousands of compounds for hypobetalipoproteinemic or hyperalphalipoproteinemic activity in rats.
- Testing compounds for antiatherosclerotic and hypocholesterolemic activity in SEA quail, followed by lipoprotein modifying activity assessment in cynomolgus monkeys.
Main Results:
- The system screens numerous compounds annually across different animal models.
- Compounds demonstrating activity in both rats and quail are advanced for further testing.
- Non-toxic compounds with significant lipoprotein modifying activity in monkeys are identified for potential clinical trials.
Conclusions:
- The developed integrated system aims to increase the likelihood of identifying effective antiatherosclerosis drugs.
- While not guaranteeing efficacy in humans, the system is designed to improve the probability of success in clinical trials.
- This approach represents a strategic advancement in the development of novel antiatherosclerosis therapies.