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Systemic reactions to subcutaneous allergen immunotherapy.
David I Bernstein1, Tolly Epstein
1Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0563, USA. bernstdd@uc.edu
Immunology and Allergy Clinics of North America
|May 3, 2011
Summary
Subcutaneous allergen immunotherapy (SCIT) is effective for allergies but carries risks of severe reactions. This review examines the incidence and causes of these serious systemic reactions to improve patient safety.
Area of Science:
- Allergy and Immunology
- Clinical Medicine
- Public Health
Background:
- Subcutaneous allergen immunotherapy (SCIT) has a century-long history.
- Established efficacy of SCIT in managing allergic rhinitis and asthma symptoms from aeroallergens.
- Clinical benefits are counterbalanced by risks of systemic reactions, including anaphylaxis.
Purpose of the Study:
- To review data on the incidence, prevalence, and contributing factors of fatal and near-fatal systemic reactions to SCIT.
- To analyze findings from retrospective surveys and ongoing longitudinal surveillance studies of SCIT reactions.
Main Methods:
- Retrospective survey data analysis.
- Review of longitudinal surveillance studies on SCIT reactions.
Main Results:
- Data from retrospective surveys and surveillance studies were reviewed to assess SCIT reaction risks.
- Focus on identifying factors associated with severe systemic and fatal anaphylactic reactions.
Conclusions:
- Understanding the risks associated with SCIT is crucial for improving patient safety.
- Further surveillance is needed to mitigate severe adverse events in allergen immunotherapy.
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