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Updated: Jun 2, 2026

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
Published on: March 6, 2015
[Morphological peculiarities of mesenteric lymph nodes in hypokinesia modeling]
Abstract:
Using histological methods, qualitative and quantitative changes in cell composition were studied in mesenteric lymph nodes in 20 male Wistar rats after experimental 30 days-long hypokinesia, and in 10 rats 1 month following the cessation of mobility restriction. Hypokinesia was found to result in massive destruction of lymphoid cells in the structural organ zones, suppression of lymphocytopoiesis, reduction in plasma cell and macrophage numbers, indicating the dampening of the immune reactions, however the full restoration of the cytoarchitectonics in the structural zones of lymph nodes did not take part 30 days following the cessation of hypokinesia.
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