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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.

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Related Experiment Video

Updated: Jun 2, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Melanoma margin assessment.

Martin J Trotter1

  • 1Department of Pathology and Laboratory Medicine, University of Calgary, Calgary Laboratory Services, Alberta, Canada. martin.trotter@cls.ab.ca

Clinics in Laboratory Medicine
|May 10, 2011
PubMed
Summary
This summary is machine-generated.

Accurate assessment of surgical margins is vital for primary cutaneous melanoma treatment. En face sectioning and immunohistochemistry improve margin evaluation, especially on sun-damaged skin.

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Area of Science:

  • Dermatopathology
  • Surgical Pathology

Background:

  • Primary cutaneous melanoma treatment relies on excisional surgery.
  • Accurate assessment of surgical margins is critical for pathology reports.
  • Conventional margin assessment methods sample only a small portion of the specimen.

Purpose of the Study:

  • To evaluate advanced techniques for surgical margin assessment in primary cutaneous melanoma.
  • To address challenges in margin assessment for melanomas on sun-damaged skin.
  • To highlight the utility of en face sectioning and immunohistochemistry.

Main Methods:

  • Review of conventional transverse (bread-loaf) vertical sections.
  • Evaluation of en face vertical and oblique sectioning techniques.
  • Discussion of diagnostic pitfalls in sun-damaged skin, including solar melanocytic hyperplasia and lichenoid reactions.
  • Consideration of frozen sections and immunohistochemistry as ancillary methods.

Main Results:

  • En face techniques allow assessment of nearly 100% of the surgical margin.
  • Margin assessment is particularly challenging on chronically sun-damaged skin.
  • Immunohistochemistry aids in identifying in situ melanoma within surgical margins.
  • Experienced clinicians may utilize frozen sections for margin assessment.

Conclusions:

  • En face sectioning offers superior margin assessment compared to conventional methods.
  • Specialized techniques, including immunohistochemistry, are essential for accurate melanoma margin evaluation, particularly in difficult cases.
  • Improved margin assessment contributes to better patient outcomes in primary cutaneous melanoma management.