Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C1qa□ muscularis macrophages maintain enteric synaptic homeostasis to regulate gastrointestinal motility.

bioRxiv : the preprint server for biology·2026
Same author

Changes in interstitial cells of Cajal calcium activity in a diabetic mouse model of delayed gastric emptying.

The Journal of physiology·2026
Same author

Heterogeneity of Muscularis Macrophages in the Stomach.

Gastro hep advances·2026
Same author

An Open-Label Trial of Effects of Varenicline in Nonconstipation Irritable Bowel Syndrome and Pain.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Defining key qualities for transformational leadership: LLIFE leadership competencies approach.

BMJ leader·2026
Same author

Feature tracking-based motility analysis of excised intestinal tissue using video recordings.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Emergency Surgical Cricothyrotomy Videos Online: Reliability and Training Quality Evaluation.

The Journal of surgical research·2026
Same journal

Management of Concomitant Traumatic Abdominal Vascular and Gastrointestinal Injuries: A Descriptive Study.

The Journal of surgical research·2026
Same journal

Article Processing Charges in General Surgery Journals: Implications for Equitable Publishing Access in Low-Income and Middle-Income Countries.

The Journal of surgical research·2026
Same journal

Association of Distal Internal Carotid Artery Tortuosity With Carotid Artery Stenting Outcomes.

The Journal of surgical research·2026
Same journal

Appendectomy and Subsequent Type 2 Diabetes - A National Cohort study.

The Journal of surgical research·2026
Same journal

Perceptions and Barriers to Intraoperative Non-technical Skills Feedback in General Surgery: A Mixed-Methods Study.

The Journal of surgical research·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

Hydrogen sulfide modulates contractile function in rat jejunum.

Michael S Kasparek1, David R Linden, Gianrico Farrugia

  • 1Department of Surgery and Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55902, USA.

The Journal of Surgical Research
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Hydrogen sulfide (H(2)S) suppresses rat jejunal muscle contractions. While its exact inhibitory mechanism remains unclear, H(2)S appears to act directly on smooth muscle cells.

More Related Videos

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer
07:55

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

Published on: May 7, 2020

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

Related Experiment Videos

Last Updated: Jun 2, 2026

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer
07:55

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

Published on: May 7, 2020

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

Area of Science:

  • Gastroenterology
  • Physiology
  • Pharmacology

Background:

  • Hydrogen sulfide (H(2)S) is recognized as a crucial gasotransmitter in the gastrointestinal tract.
  • The precise role and mechanisms of H(2)S in regulating gut contractile function are not fully elucidated.

Purpose of the Study:

  • To investigate the effects of exogenous H(2)S on rat jejunal muscle contractile activity.
  • To elucidate the underlying mechanisms of H(2)S action, including its interaction with neurotransmitters and ion channels.

Main Methods:

  • Assessment of spontaneous and stimulated contractile activity in rat jejunal muscle strips.
  • Application of sodium hydrosulfide (NaHS) as an H(2)S donor and various pharmacological agents (e.g., glibenclamide, L-N(G)-nitro arginine, neurotransmitter antagonists) to probe mechanisms.
  • Investigation of endogenous H(2)S production using enzyme inhibitors and substrates.
  • Immunohistofluorescence to localize H(2)S-producing enzymes.

Main Results:

  • Exogenous H(2)S (NaHS) significantly suppressed both spontaneous and stimulated jejunal contractile activity.
  • Glibenclamide partially blocked H(2)S-induced suppression of stimulated contractions but not spontaneous ones.
  • Inhibition of endogenous H(2)S synthesis affected basal and stimulated jejunal activity, suggesting a role for endogenous H(2)S.
  • Blocking neurotransmitters potentiated H(2)S inhibitory effects.

Conclusions:

  • H(2)S exerts inhibitory effects on rat jejunal smooth muscle contractility.
  • The precise molecular mechanisms of H(2)S inhibition are complex and not fully explained by direct smooth muscle effects or blockade of ATP-sensitive K(+)-channels.
  • Further research is needed to fully understand the signaling pathways involved in H(2)S-mediated gut motility regulation.