Role of Purinergic Signaling in Voiding Dysfunction
1Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Current Bladder Dysfunction Reports
|May 17, 2011
Summary
Purinergic signaling, involving adenosine triphosphate, is linked to bladder dysfunction. Targeting this pathway offers potential treatments for various bladder disorders.
Area of Science:
- Urology
- Neuroscience
- Pharmacology
Background:
- Purinergic signaling involves adenosine triphosphate (ATP) binding to purinergic receptors (P2X, P2Y).
- This signaling pathway is implicated in several bladder functional disorders.
Purpose of the Study:
- To review the role of purinergic signaling in bladder function and dysfunction.
- To explore potential therapeutic targets within this pathway for bladder disorders.
Main Methods:
- Literature review of studies on purinergic signaling and bladder function.
- Analysis of the involvement of purinergic signaling in conditions like interstitial cystitis, neurogenic bladder, and lower urinary tract symptoms.
Main Results:
- Purinergic signaling is active in the central nervous system, peripheral nerves, detrusor smooth muscle, and bladder urothelium.
- Dysregulation of purinergic signaling is associated with conditions such as painful bladder syndrome, spinal cord injury-related neurogenic bladder, LUTS, diabetes, and aging.
Conclusions:
- Purinergic signaling is a key player in bladder physiology and pathology.
- Targeting purinergic signaling at various anatomical sites presents a promising therapeutic strategy for treating diverse bladder functional disorders.
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