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Updated: Jun 1, 2026
11:04
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
(E)-N'-(5-Bromo-2-methoxy-benzyl-idene)-4-methoxy-benzohydrazide
Summary
This study details the crystal structure of a novel benzohydrazide compound. The molecule exhibits a non-planar benzohydrazide group and forms hydrogen-bonded chains in its solid state.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Benzohydrazide derivatives are important scaffolds in medicinal chemistry.
- Understanding the solid-state structure is crucial for drug design and material science.
Purpose of the Study:
- To elucidate the three-dimensional molecular and crystal structure of the title compound, C(16)H(15)BrN(2)O(3).
- To investigate the intermolecular interactions governing the crystal packing.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed.
- The crystal structure was solved and refined to determine atomic positions and bonding.
Main Results:
- The benzohydrazide moiety was found to be non-planar, adopting a trans configuration around the methylidene unit.
- A significant dihedral angle of 75.6(2)° was observed between the two substituted benzene rings.
- Intermolecular N-H⋯O hydrogen bonds between carbonyl and amine groups resulted in the formation of chains along the c cell axis.
Conclusions:
- The study provides a detailed structural characterization of the title benzohydrazide compound.
- The identified hydrogen bonding network offers insights into the supramolecular assembly and potential for crystal engineering.
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