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Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
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Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
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Published on: February 14, 2015

A functional, nonfunctioning Retisert implant.

Carolyn B Hebson1, Sunil K Srivastava

  • 1Department of Ophthalmology, Emory University, Atlanta, Georgia, USA. hebson@bcm.edu

Ocular Immunology and Inflammation
|May 21, 2011
PubMed
Summary
This summary is machine-generated.

The fluocinolone acetonide (Retisert™) implant treats chronic uveitis. Device malfunction can cause persistent inflammation, but replacement with a functioning implant resolved symptoms in a reported case.

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Area of Science:

  • Ophthalmology
  • Inflammatory Eye Diseases
  • Drug Delivery Systems

Background:

  • The fluocinolone acetonide (Retisert™) implant is indicated for chronic, posterior, non-infectious uveitis.
  • Persistent ocular inflammation can occur post-implantation, with suspected device malfunction being a potential cause.

Observation:

  • A patient experienced ongoing inflammation despite Retisert™ implantation.
  • This persistent inflammation was suspected to be linked to a malfunctioning implant.

Findings:

  • Device exchange was performed, replacing the suspected malfunctioning implant with a new, functional fluocinolone acetonide implant.
  • Following the explant analysis and replacement, the patient's inflammation subsided.

Implications:

  • This case highlights the possibility of Retisert™ implant malfunction contributing to persistent uveitis.
  • Device exchange with a functional implant can be an effective strategy to manage refractory inflammation.
  • Further investigation into implant performance and potential failure modes is warranted.