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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: May 11, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Histamine in allergic rhinitis.

Thomas Taylor-Clark1

  • 1Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, Florida 33612, USA. ttaylorc@health.usf.edu

Advances in Experimental Medicine and Biology
|May 31, 2011
PubMed
Summary
This summary is machine-generated.

Histamine is key in allergic rhinitis, causing nasal symptoms when released by mast cells. Understanding histamine receptors in the nasal mucosa is crucial for managing this condition.

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Last Updated: May 11, 2026

Basophil Activation Test for Allergy Diagnosis
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Published on: May 31, 2021

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

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Published on: June 29, 2021

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Area of Science:

  • Immunology
  • Allergology
  • Pharmacology

Background:

  • Histamine is a primary mediator in allergic rhinitis.
  • Allergen exposure triggers histamine release from nasal mast cells.
  • Histamine administration replicates allergic rhinitis symptoms.

Purpose of the Study:

  • To discuss the role of histamine in allergic rhinitis.
  • To explore the function of all four histamine receptors in nasal mucosa.
  • To elucidate the pathophysiology of allergic rhinitis concerning histamine.

Main Methods:

  • Review of existing literature on histamine and allergic rhinitis.
  • Analysis of studies involving allergen challenges.
  • Examination of research on histamine receptor distribution and function in the nasal mucosa.

Main Results:

  • Histamine is demonstrably present in the nasal mucosa following allergen exposure.
  • Exogenous histamine administration induces symptoms consistent with allergic rhinitis.
  • All four histamine receptor subtypes are present in the nasal mucosa.

Conclusions:

  • Histamine significantly contributes to the signs and symptoms of allergic rhinitis.
  • The four histamine receptors play distinct roles in the nasal pathophysiology of allergic rhinitis.
  • Targeting histamine receptors may offer therapeutic strategies for allergic rhinitis.