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Updated: Jun 1, 2026
05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Case-control study of the relationship between children's moderate-severe asthma and development indicators]
Xue-jun Wu1, Ying Huang, Ying Wang
1Children's Hospital of Chongqing Medical University Key Laboratory of Developmental Diseases in Childhood (Chongqing Medical University), Ministry of Education, Chongqing 400014, China.
Summary
Children with severe asthma show significantly lower height and weight compared to those with moderate asthma or healthy peers. This highlights potential developmental impacts of severe asthma in pediatric populations.
Area of Science:
- Pediatric Pulmonology
- Child Development
- Asthma Research
Context:
- Asthma is a common chronic respiratory disease in children.
- Severe persistent asthma can impact a child's overall health and development.
- Understanding growth patterns in asthmatic children is crucial for effective management.
Purpose:
- To investigate the relationship between the severity of persistent asthma and the physical development of children.
- To compare the height, weight, and lung function of children with moderate-to-severe asthma against a healthy control group.
Summary:
- A study involving 389 children with moderate-to-severe persistent asthma and 298 healthy controls assessed physical development across different age groups (3, 5, and 7-10 years).
- Results indicated that children in the severe asthma group exhibited significantly lower height and weight measurements compared to both the moderate asthma group and the healthy control group across all age brackets.
- While children with moderate asthma showed a trend towards lower height and weight than controls, these differences were not statistically significant, suggesting a dose-dependent effect of asthma severity on physical development.
Impact:
- Findings underscore the detrimental effect of severe asthma on pediatric growth and development.
- Highlights the need for monitoring growth parameters in children with severe asthma.
- Informs clinical practice regarding comprehensive care for pediatric asthma patients.
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