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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jun 1, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

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Taking HSCs down a Notch in leukemia.

Carl R Walkley¹, David J Izon, Louise E Purton

¹St. Vincent's Institute of Medical Research and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, VIC 3065, Australia.

|June 1, 2011

Summary

This summary is machine-generated.

The Notch signaling pathway, often active in T-ALL, surprisingly acts as a tumor suppressor in myeloid cancers. This finding adds complexity to understanding Notch

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Area of Science:

Oncology
Molecular Biology
Hematopoiesis

Background:

The Notch signaling pathway is frequently activated in T cell acute lymphoblastic leukemias (T-ALL).
Recent research indicates a complex role for Notch signaling in hematopoiesis.

Discussion:

Klinakis et al. (2011) revealed a novel tumor-suppressor function for the Notch pathway.
This function was demonstrated specifically within the context of myeloid malignancies.

Key Insights:

The Notch pathway exhibits context-dependent roles in cancer, acting as an oncogene in T-ALL but a tumor suppressor in myeloid cancers.
This discovery challenges previous assumptions and highlights the intricate nature of signaling pathways in different hematological malignancies.

Outlook:

Further investigation into the molecular mechanisms underlying Notch's dual role is warranted.
This research may open new therapeutic avenues for myeloid malignancies by targeting the Notch pathway.