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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

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Beating cancer in multiple ways using nanogold.

Erik C Dreaden1, Megan A Mackey, Xiaohua Huang

  • 1Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.

Chemical Society Reviews
|June 2, 2011
PubMed
Summary
This summary is machine-generated.

Gold nanoparticles are versatile anti-cancer agents. They function as contrast agents for photothermal therapy, drug delivery scaffolds, gene therapy agents, and direct antineoplastic agents, showcasing their multifunctional potential.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Gold nanoparticles exhibit unique properties making them highly multifunctional anti-cancer agents.
  • Their applications span photothermal therapy, drug delivery, gene therapy, and direct anti-cancer effects.

Purpose of the Study:

  • To review the diverse forms and recent applications of gold nanoparticle conjugates in cancer therapy.
  • To discuss the rational design and physiological interactions of these nanoconjugates.

Main Methods:

  • Literature review of gold nanoparticle applications in cancer research.
  • Highlighting studies on targeted contrast agents, drug delivery scaffolds, and gene therapy vectors.
  • Discussion of rational design principles and physiological interactions.

Main Results:

  • Gold nanoparticles serve as effective platforms for photothermal cancer therapy.
  • They act as scaffolds for enhanced drug delivery and as transfection agents for gene therapy.
  • These nanoparticles demonstrate intrinsic antineoplastic properties.

Conclusions:

  • Gold nanoparticle conjugates represent a promising multifunctional approach to cancer treatment.
  • Further research into their design and interactions will optimize their therapeutic potential.
  • The versatility of gold nanoparticles offers significant opportunities in oncology.