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Related Experiment Videos

Oxidant-induced increases in mucosal permeability in developing piglets.

E S Clark1, K D Crissinger, D N Granger

  • 1Department of Physiology/Biophysics, Louisiana State University Medical Center, Shreveport 71130-3932.

Pediatric Research
|July 1, 1990
PubMed
Summary
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Neonatal piglets

Area of Science:

  • Gastroenterology
  • Neonatal Physiology
  • Oxidative Stress

Background:

  • Reactive oxygen metabolites contribute to mucosal injury, particularly in neonatal necrotizing enterocolitis.
  • Neonatal piglets have a limited capacity to detoxify hydrogen peroxide (H2O2) compared to older animals.

Purpose of the Study:

  • To investigate the vulnerability of the neonatal piglet intestine to oxidant-induced mucosal injury.
  • To compare the effects of hydrogen peroxide (H2O2) and hypochlorous acid on intestinal permeability in piglets of different ages.

Main Methods:

  • Luminal perfusion of distal ileum with H2O2 and hypochlorous acid in 1-day-old and 1-month-old piglets.
  • Quantification of mucosal permeability using 51-chromium EDTA blood-to-lumen clearance.

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Main Results:

  • Luminal H2O2 and hypochlorous acid increased mucosal permeability in newborn piglets but not in 1-month-old piglets at lower concentrations.
  • Higher concentration H2O2 perfusion significantly increased permeability in both age groups, with greater injury in newborns.

Conclusions:

  • The neonatal piglet ileum is more susceptible to oxidant-induced mucosal injury due to reduced H2O2 detoxification capacity.
  • Findings support the role of oxidants in neonatal intestinal injury and highlight age-related differences in mucosal defense.