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Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

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Related Experiment Video

Updated: May 31, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Dentin-pulp complex regeneration: from lab to clinic.

S R J Simon1, A Berdal, P R Cooper

  • 1INSERM, UMR S, Centre de recherche des Cordeliers, Paris, France. stephane.simon@univ-paris-diderot.fr

Advances in Dental Research
|June 17, 2011
PubMed
Summary
This summary is machine-generated.

Advances in biotechnology are revolutionizing dentistry, offering new pulp healing therapies. Understanding odontoblast gene regulation and the p38 MAPKinase pathway is key for clinical translation.

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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
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Related Experiment Videos

Last Updated: May 31, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

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Published on: January 12, 2017

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

Area of Science:

  • Biotechnology in Dentistry
  • Dental Pulp Biology
  • Regenerative Medicine

Background:

  • Pulp healing is a complex process influenced by injury extent and cellular responses.
  • Molecular and cellular mechanisms underlying pulp healing often mirror developmental processes.
  • Odontoblast activity regulation is crucial for effective pulp healing and therapeutic strategies.

Purpose of the Study:

  • To explore the role of biotechnology in advancing dental therapies.
  • To understand the molecular mechanisms regulating odontoblast activity during pulp healing.
  • To identify potential therapeutic targets for enhanced pulp regeneration.

Main Methods:

  • Transcriptome analysis to identify gene expression changes in odontoblasts.
  • Investigation of the p38 MAPKinase pathway's role in transcriptional control.
  • Review of recent advances in pulpal stem cells and molecular signaling.

Main Results:

  • Transcriptome analysis revealed significant odontoblast gene expression changes in response to injury.
  • The p38 MAPKinase pathway was identified as central to odontoblast transcriptional control.
  • Recent discoveries highlight opportunities for translating pulpal stem cell research into clinical applications.

Conclusions:

  • The p38 MAPKinase pathway presents a promising therapeutic target for pulp healing.
  • Advances in understanding pulpal stem cells and signaling molecules enable novel therapies.
  • Collaboration between researchers and clinicians is essential for successful clinical translation of new dental treatments.