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The effect of Hypericum perforatum on isolated rat aorta
Ibrahim Tugrul1, Buket Demirci, Omer Demir
1Department of Pharmacology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
Pharmaceutical Biology
|June 24, 2011
Summary
Standardized Hypericum perforatum (HP) extract significantly reduced vascular contraction without harming endothelium or smooth muscle function. These findings suggest potential benefits for conditions involving increased vascular tone.
Area of Science:
- Pharmacology
- Cardiovascular Research
- Herbal Medicine
Background:
- Hypericum species, including Hypericum perforatum (HP), are traditional medicines in Turkey.
- Investigating the vascular effects of standardized HP extract is crucial for understanding its therapeutic potential.
Purpose of the Study:
- To evaluate the impact of standardized Hypericum perforatum extract on vascular and endothelial function.
- To assess the safety and efficacy of HP on vascular contractility and relaxation.
Main Methods:
- Aortic rings with endothelium were isolated and suspended in Krebs solution.
- Contractile responses to phenylephrine and potassium chloride were measured.
- Relaxant responses to acetylcholine and sodium nitroprusside were assessed in the presence and absence of HP extract.
Main Results:
- HP extract significantly reduced contractile responses to phenylephrine and potassium chloride (p < 0.05).
- No significant alterations were observed in relaxant responses to acetylcholine and sodium nitroprusside.
- High doses of HP extract did not adversely affect endothelium or smooth muscle function.
Conclusions:
- Standardized Hypericum perforatum extract demonstrates a potential to reduce vascular hypercontractility.
- The extract appears safe for vascular and smooth muscle function at the tested concentrations.
- HP may offer therapeutic benefits for diseases characterized by increased vascular contraction.
