Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization and response to exercise training of HDL-specific phospholipid efflux.

Journal of lipid research·2026
Same author

N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness.

Circulation·2025
Same author

Variation in cycling exercise mechanical efficiency in the HERITAGE Family Study.

Physiological reports·2025
Same author

Association of the HDL lipidome with HDL traits before and after exercise training: HERITAGE family study.

Metabolomics : Official journal of the Metabolomic Society·2025
Same author

Polygenic prediction of body mass index and obesity through the life course and across ancestries.

Nature medicine·2025
Same author

Mechanical efficiency: associations with body composition and glycemic profile in healthy adults.

European journal of applied physiology·2024
Same journal

Limb Disuse Trials in Humans: Key Insights on Study Design, Ethics, and Project Execution.

Exercise and sport sciences reviews·2026
Same journal

Integrating Astronomical Seasonal Phase into Physical Activity Research.

Exercise and sport sciences reviews·2026
Same journal

microRNA-1: A Master Regulator of Metabolism Governing Skeletal Muscle Hypertrophy.

Exercise and sport sciences reviews·2026
Same journal

Acute Exercise and Cognitive Improvement: A Neuromodulatory Perspective.

Exercise and sport sciences reviews·2026
Same journal

Cognitive Neuroelectrical Activity During Preparation for Exercise Under Hyperthermia.

Exercise and sport sciences reviews·2026
Same journal

Breaking Boundaries Between Resistance and Aerobic Training in Cancer Survivors.

Exercise and sport sciences reviews·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
02:47

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

Overcoming barriers to progress in exercise genomics.

Claude Bouchard1

  • 1Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. claude.bouchard@pbrc.edu

Exercise and Sport Sciences Reviews
|June 24, 2011
PubMed
Summary
This summary is machine-generated.

This commentary discusses improving statistical power and exploring beyond common DNA variants in exercise genomics. It highlights combining transcriptomics with genomics for better genotype-phenotype links.

More Related Videos

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

Related Experiment Videos

Last Updated: May 31, 2026

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
02:47

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

Area of Science:

  • Exercise Genomics
  • Human Genetics
  • Molecular Biology

Background:

  • Exercise genomics research faces challenges in establishing genotype-phenotype relationships.
  • Current research often overlooks the importance of statistical power and hypothesis-free approaches.

Purpose of the Study:

  • To address key issues in exercise genomics research.
  • To advocate for advanced methodologies for robust genetic association studies.

Main Methods:

  • Discussion of statistical power considerations in genetic studies.
  • Evaluation of hypothesis-free methods like genome-wide association studies (GWAS).
  • Exploration of integrating transcriptomics with genomics.

Main Results:

  • Statistical power is crucial for reliable exercise genomics findings.
  • Hypothesis-free approaches can be useful but require careful interpretation.
  • Expanding research to include rare DNA variants is necessary.
  • Combining transcriptomics and genomics offers a more comprehensive view.

Conclusions:

  • Enhancing statistical power and broadening genetic variant analysis are essential for progress in exercise genomics.
  • Integrated genomic and transcriptomic approaches are vital for understanding genotype-phenotype correlations in exercise response.