[Immunosenescence. Current status and molecular mechanisms]

One of the most important biological changes occurring during human aging is termed 'immunosenescence' characterized by a functional decline in immunity leading to a progressive immunodeficiency. Regulatory mechanisms also are diminished, leading to an inefficient and poorly controlled pro-inflammatory activation of the immune response. This increases the risk for disorders such as infectious, autoimmune, neoplastic, cardiovascular and neurodegenerative disease. Many of these entities are quite relevant for dermatology. Hence, immunosenescence constitutes a pathologic process contributing to morbidity and mortality of important clinical relevance in an aging population. Investigation of the underlying pathomechanisms and the application of modern mechanism-directed therapy offer many opportunities for a targeted modulation and "rejuvenation", thus indicating possible targets for the reduction of age-associated morbidity and mortality. Some promising targeted 'molecular' therapies are already currently being used in the context of other diseases, also in the field of dermatology.