Related Experiment Video
Updated: May 31, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
[Prognostic and predictive factors in multifocal breast carcinoma]
C Moutafoff1, C Coutant, C Bézu
1Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, AP-HP, université Pierre-et-Marie-Curie Paris-6, 4 rue de la Chine, Paris, France.
Gynecologie, Obstetrique & Fertilite
|July 15, 2011
Summary
Multicentric breast cancer significantly increases lymph node involvement risk by 20%. This finding suggests adjuvant chemotherapy for all multicentric breast cancer cases, regardless of tumor size, warrants further study.
Area of Science:
- Oncology
- Breast Cancer Research
Background:
- Multicentricity is not a primary prognostic factor for invasive breast carcinoma.
- Current guidelines do not universally recommend systemic adjuvant treatment based solely on multicentricity.
Purpose of the Study:
- To determine the prognostic value of multicentricity in invasive breast carcinoma.
- To compare different measurement methods for multicentric breast carcinomas.
Main Methods:
- Analysis of 1458 patients with invasive breast carcinoma (2001-2008).
- Comparison of multicentricity's impact on lymph node (LN) involvement.
- Evaluation of three distinct methods for measuring multicentric tumors.
Main Results:
- Multicentricity showed a significant association with lymph node involvement.
- Patients with multicentric cancer had a 20% increased risk of LN involvement, irrespective of tumor size.
- Measuring the diameter of the largest tumor focus emerged as the optimal method.
Conclusions:
- No low-risk subgroup identified for lymph node involvement in multicentric breast cancer.
- Expanded indications for adjuvant chemotherapy in all multicentric breast cancer cases are suggested.
- Further validation through randomized prospective studies is recommended.
