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Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

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Related Experiment Video

Updated: May 30, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Implanted renal replacement for end-stage renal disease.

S Roy1, K Goldman, R Marchant

  • 1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. fisselw@ccf.org

Panminerva Medica
|July 22, 2011
PubMed
Summary

An implantable artificial kidney could improve survival for dialysis patients. Advances in biomimetic membranes, blood-material interactions, and cell function are key to developing this life-saving technology.

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09:43

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Published on: August 10, 2015

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nephrology

Background:

  • Patients on dialysis face high mortality rates from cardiovascular and infectious causes.
  • Current home dialysis is limited by patient concerns regarding skill and safety.
  • An implantable artificial kidney offers intensive therapy benefits while addressing patient fears.

Purpose of the Study:

  • To explore the technological advancements required for an implantable artificial kidney.
  • To identify key areas of development for creating a functional artificial kidney device.
  • To assess the feasibility of using biomimetic membranes and engineered cells for kidney replacement therapy.

Main Methods:

  • Reviewing progress in hollow fiber polymer membranes and dialytic waste removal.
  • Investigating biomimetic membranes and living cells for replicating native kidney function.
  • Examining advancements in ultrafiltration membranes, blood-material interactions (thrombosis, fouling), and stable cell function.

Main Results:

  • Significant progress has been made in proof-of-concept experiments for key technologies.
  • Hollow fiber membranes, while effective, present challenges for implantable applications.
  • Biomimetic approaches using cells show promise for replicating kidney waste removal strategies.

Conclusions:

  • Developing an implantable artificial kidney requires breakthroughs in ultrafiltration, blood compatibility, and engineered cell function.
  • Proof-of-concept studies indicate feasibility for these critical technological areas.
  • An artificial kidney holds potential to significantly improve outcomes for patients requiring dialysis.