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Genetic mutations and functions of PINK1

Sumihiro Kawajiri1, Shinji Saiki, Shigeto Sato

  • 1Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Japan.

Trends in Pharmacological Sciences
|July 26, 2011
PubMed
Summary

Mutations in PTEN-induced kinase 1 (PINK1) cause young-onset Parkinson's disease. PINK1 and parkin proteins maintain mitochondrial health through mitophagy, offering potential therapeutic targets for Parkinson's disease.

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