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Pregnancy-associated plasma protein-A levels in individuals with and without coronary artery disease

Najeeb Ullah Khan1, Farooq Ahmad Khan, Dilshad Ahmed Khan

  • 1Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi. dr_najeebkhan@hotmail.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 30, 2011
PubMed

Insights

Pregnancy-associated plasma protein-A (PAPP-A) levels are significantly higher in individuals with coronary artery disease (CAD). Elevated PAPP-A may serve as a marker for atherosclerosis presence and extent.

Area of Science:

  • Biochemistry
  • Cardiology
  • Clinical Pathology

Background:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • Biomarkers are crucial for diagnosing and managing cardiovascular conditions.
  • Pregnancy-associated plasma protein-A (PAPP-A) is a protein with potential roles in cardiovascular pathophysiology.

Purpose of the Study:

  • To investigate and compare serum levels of PAPP-A in patients with and without diagnosed CAD.
  • To evaluate the diagnostic potential of PAPP-A as a biomarker for atherosclerotic coronary artery disease.

Main Methods:

  • A cross-sectional comparative study involving 125 participants was conducted.
  • Blood samples were collected for PAPP-A and lipid profile analysis prior to coronary angiography.
  • PAPP-A levels were measured using Enzyme Linked Immunosorbent Assay (ELISA).

Main Results:

  • Individuals with CAD (n=84) exhibited significantly higher mean PAPP-A levels (1.35 ± 0.57 mIU/L) compared to those without CAD (n=41, 0.74 ± 0.35 mIU/L) (p < 0.001).
  • A PAPP-A cutoff level of 0.85 mIU/L demonstrated 78% sensitivity and 70% specificity for diagnosing atherosclerotic CAD.
  • Lipid profiles were also analyzed using automated analyzers.

Conclusions:

  • Serum PAPP-A levels are elevated in individuals with coronary artery disease.
  • PAPP-A is a potential biomarker for the presence and extent of coronary atherosclerosis.
  • Further research may elucidate the precise role of PAPP-A in CAD pathogenesis and management.
Abstract

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