Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Transgenic Plants

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

Plant Breeding and Biotechnology

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phenotypic and genotypic detection of antibiotic-resistant bacteria in fresh fruit juices from a public hospital in Rio de Janeiro.

Archives of microbiology·2021

Same author

Molecular Detection, Typing, and Quantification of Campylobacter spp. in Foods of Animal Origin.

Comprehensive reviews in food science and food safety·2020

Same author

[The risk of biogenic amines in food].

Ciencia & saude coletiva·2014

Same author

[Policies and standards applied to municipal day care centers in Rio de Janeiro].

Ciencia & saude coletiva·2013

Same author

[The lack of information on genetically modified organisms in Brazil].

Ciencia & saude coletiva·2012

Same author

[Labeling of food containing genetically modified organisms: international policies and Brazilian legislation].

Ciencia & saude coletiva·2011

Search research articles

Related Experiment Video

Updated: May 30, 2026

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

[Transgenics - Plant-Based Drugs (PBD)].

Daniele Rachidi da Rocha¹, Victor Augustus Marin

¹Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. danielerachidi@yahoo.com.br

Ciencia & Saude Coletiva

|August 3, 2011

Summary

Plant-Based Drugs (PBDs) are a fourth-generation technology using genetically modified plants for pharmaceutical production. Comprehensive risk analysis and management are crucial for the safe application of this innovation.

Area of Science:

Biotechnology and Genetic Engineering
Pharmaceutical Sciences
Plant Molecular Biology

Context:

Introduction of Plant-Based Drugs (PBDs) as the fourth generation of genetically modified plants.
Application of PBD technology for developing and producing pharmaceuticals, vaccines, and products from transgenic seeds.
Acknowledgement of inherent risks associated with scientific innovations.

Purpose:

To analyze the applicability of PBD technology.
To evaluate risk management and containment strategies for PBDs.
To ensure the safe use, handling, and consumption of PBD products by humans.

Summary:

PBDs represent a significant advancement in biotechnology, utilizing transgenic plants for pharmaceutical and vaccine production.

More Related Videos

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Published on: March 28, 2018

Related Experiment Videos

Last Updated: May 30, 2026

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Published on: March 28, 2018

Current knowledge regarding the specific risks, their significance, and likelihood of harm from PBDs is limited, necessitating a precautionary approach.

Thorough risk analysis, parameter evaluation, and broad-ranging research are essential before implementing PBD technology.

Impact:

Highlights the need for robust risk assessment frameworks prior to the widespread adoption of PBDs.
Emphasizes the importance of containment and safety protocols in biotechnological innovations.
Contributes to the discourse on responsible innovation in the development of plant-derived pharmaceuticals.