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Published on: August 24, 2019
Pulmonary hypertension in a stable community-based COPD population
Vadim Fayngersh1, Fotios Drakopanagiotakis, F Dennis McCool
1Division of Pulmonary, Sleep and Critical Care Medicine, The Memorial Hospital of Rhode Island, Pawtucket, RI, USA.
Lung
|August 5, 2011
Summary
Pulmonary hypertension (PH) affects 60% of patients with chronic obstructive pulmonary disease (COPD). Older age and severe airway obstruction increase the risk of developing PH in COPD patients.
Area of Science:
- Pulmonary Medicine
- Cardiology
Background:
- Pulmonary hypertension (PH) is a complex condition with uncertain prevalence in stable chronic obstructive pulmonary disease (COPD).
- Understanding the relationship between PH and pulmonary function is crucial for managing COPD patients.
Purpose of the Study:
- To determine the prevalence of PH in outpatients with stable COPD.
- To evaluate the association between PH and various indices of pulmonary function in COPD patients.
Main Methods:
- Retrospective review of stable COPD outpatients meeting GOLD criteria for airway obstruction.
- Echocardiogram within 6 months of pulmonary function tests (PFTs) to assess systolic pulmonary artery pressure (sPAP).
- PH defined as sPAP ≥36 mmHg; exclusion of patients with left ventricular ejection fraction (LVEF) ≤55%.
Main Results:
- Prevalence of PH was 60% (63/105) in the study cohort.
- COPD patients with PH were older and had significantly lower FEV(1)% predicted and % predicted DL(CO).
- Age and prebronchodilator FEV(1)% predicted were significant predictors of PH by logistic regression.
Conclusions:
- Pulmonary hypertension is highly prevalent in patients with stable COPD.
- Older age and greater airway obstruction are key risk factors for developing PH in COPD.
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