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Updated: May 30, 2026

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells
Published on: February 23, 2011
Asymmetric synthesis and sensory evaluation of sedanenolide
Daichi Oguro1, Hidenori Watanabe
1Technical Research Institute, R&D Center, T. Hasegawa Co., Ltd, Nakahara-ku, Kawasaki, Kanagawa, Japan.
Abstract:
The synthesis and sensory evaluation of enantiomeric sets of sedanenolide (1) and 3-butylphthalide (3) are described. The asymmetric synthesis was achieved via the intramolecular Diels-Alder reaction of chiral propargylester (5) which was prepared from optically active propargyl alcohol (4) and 2,4-pentadienoic acid. The sensory evaluation of these enantiomers revealed that there were distinct differences between their aroma character and odor threshold.
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