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Fungal toenail infections
1The University of East London, London, UK.
BMJ Clinical Evidence
|August 18, 2011
Summary
This systematic review examines oral and topical treatments for fungal toenail infections, evaluating their effectiveness and safety. It provides evidence-based information on various antifungal medications and debridement methods.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Fungal infections affect a significant percentage of patients with foot and nail conditions seen by dermatologists.
- While common in clinical settings, fungal nail conditions are less prevalent in the general population, impacting 3-5% of individuals.
Purpose of the Study:
- To systematically review the effects of oral treatments for fungal toenail infections.
- To systematically review the effects of topical treatments for fungal toenail infections.
Main Methods:
- Conducted a systematic literature review up to March 2011, searching major databases (Medline, Embase, Cochrane Library).
- Included harms alerts from regulatory agencies like the US FDA and UK MHRA.
- Evaluated the quality of evidence for interventions using the GRADE system.
Main Results:
- Identified 12 systematic reviews, randomized controlled trials (RCTs), or observational studies meeting inclusion criteria.
- Assessed the effectiveness and safety of various antifungal interventions.
Conclusions:
- Presents information on the effectiveness and safety of amorolfine, butenafine, ciclopirox, fluconazole, griseofulvin, itraconazole, ketoconazole, mechanical debridement, terbinafine, and tioconazole.
- Provides a comprehensive overview of treatment options for fungal toenail infections based on available evidence.
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