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Updated: May 30, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Engineering DNA-based functional materials.

Young Hoon Roh¹, Roanna C H Ruiz, Songming Peng

¹Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14850, USA.

Chemical Society Reviews

|August 23, 2011

Summary

This summary is machine-generated.

DNA, a genetic material, is also a versatile polymer. This review explores engineering methods and applications of DNA-based materials in nanotechnology, medicine, and biotechnology.

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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Published on: September 27, 2019

Designing a Bio-responsive Robot from DNA Origami

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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Deoxyribonucleic acid (DNA) is recognized primarily as genetic material.
The polymeric nature of DNA, composed of nucleotides, offers untapped potential for material science.
Recent advancements are beginning to leverage DNA's structural and chemical properties beyond its biological role.

Purpose of the Study:

To review engineering methods for creating DNA-based materials.
To explore diverse real-world applications of DNA as a polymeric material.
To provide a comprehensive overview for researchers entering the field.

Main Methods:

Categorization of DNA material construction based on topology (linear, branched/dendritic, networked).
Discussion of various strategies for synthesizing DNA building blocks and assembling materials.
Review of existing and potential applications across different scientific domains.

Main Results:

Demonstration of diverse DNA material architectures achievable through topological control.
Identification of key engineering strategies for DNA-based material fabrication.
Highlighting of promising applications in nanotechnology, medicine, and biotechnology.

Conclusions:

DNA's polymeric characteristics present significant opportunities for advanced material design.
Engineering DNA topologies enables the creation of novel functional materials.
DNA-based materials hold transformative potential for various technological and biomedical fields.