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The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Retinoblastoma Gene

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Accessory Structures of the Eye

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Related Experiment Video

Updated: May 30, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Orbital melanoma.

A Furdova1, M Chynoransky, P Krajcova

  • 1Department of Ophthalmology, Comenius University, Faculty of Medicine, Bratislava, Slovakia. alikafurdova@yahoo.com

Bratislavske Lekarske Listy
|August 26, 2011
PubMed
Summary

Orbital melanomas are rare tumors, accounting for less than 1% of orbital neoplasms. Most primary orbital melanomas originate from melanocytes, with only one case identified in this study of uveal melanoma patients.

Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Primary or secondary orbital melanomas are exceptionally rare, constituting less than 1% of all primary orbital neoplasms.
  • Over 90% of these rare tumors originate from melanocytes, often associated with congenital ocular melanosis or oculodermal melanosis.

Observation:

  • A study at the Department of Ophthalmology, Comenius University, Bratislava (2001-2007) reviewed 79 patients with uveal melanoma.
  • Of these, 45 (57%) with ciliary body and choroidal melanomas underwent primary enucleation.
  • 34 (43%) were treated with combined techniques or stereotactic radiosurgery alone.

Findings:

  • Primary orbital melanoma was identified in only 1 patient (1%) within the studied group of uveal melanoma patients.
  • This highlights the rarity of primary orbital melanoma even within a cohort diagnosed with uveal melanoma.

Related Experiment Videos

Last Updated: May 30, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Implications:

  • The findings underscore the need for specialized diagnostic approaches for orbital melanomas due to their extreme rarity.
  • Further research into the specific origins and optimal management strategies for these rare orbital tumors is warranted.