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Updated: May 29, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Presentation of atypical bullous pyoderma gangrenosum]
Anne Birgitte Simonsen1, Anne Braae Olesen
1Dermato-venerologisk Afdeling, Aarhus Universitetshospital, Aarhus Sygehus, 8000 Aarhus C, Denmark. annebsimonsen@hotmail.com
Abstract:
Pyoderma gangrenosum (PG) is a rare, ulcerative skin disease. Atypical PG is characterized by rapidly evolving painful vesicles and enlarging bullae. Minor trauma or surgery is considered the cause in 25-50% of PG lesions. PG often mimics necrotizing infection and may therefore be inadequately treated. We present a patient with rapidly progressing bullous PG. The lesions were initially treated surgically, which led to exacerbation of the ulcers. A decision of surgery should be preceded by bacterial culture and microscopy and in case of uncertain diagnosis also by histopathologic examination.
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