Related Experiment Video

Updated: May 29, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Estrogens and prostate cancer: etiology, mediators, prevention, and management

Shuk-Mei Ho1, Ming-Tsung Lee, Hung-Ming Lam

  • 1Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. shuk-mei.ho@uc.edu

Endocrinology and Metabolism Clinics of North America
|September 6, 2011
PubMed

Insights

Estrogen plays a key role in prostate cancer (PCa) development. This review explores how estrogens and related compounds influence prostate carcinogenesis and their potential for PCa prevention and treatment.

Area of Science:

  • Oncology
  • Endocrinology
  • Urology

Background:

  • Hormonal therapies for prostate cancer (PCa) primarily target androgen action.
  • Emerging evidence highlights significant roles for estrogens in PCa development and progression.
  • Estrogen metabolism and synthesis exhibit racial, geographic, and age-related variations influencing PCa etiology.

Purpose of the Study:

  • To summarize the contribution of various estrogens, antiestrogens, and estrogen mimics to prostate carcinogenesis.
  • To elucidate the roles of different estrogen mediators in PCa development.
  • To explore the potential of novel estrogenic and antiestrogenic compounds for PCa prevention and treatment.

Main Methods:

  • Literature review and synthesis of epidemiological and experimental data.
  • Analysis of the mechanisms by which estrogens influence prostate cancer.
  • Evaluation of existing and emerging estrogen-related compounds for therapeutic potential.

Main Results:

  • Estrogens, antiestrogens, and estrogen mimics significantly impact prostate carcinogenesis.
  • Specific mediators of estrogen action are crucial in PCa progression.
  • New estrogenic/antiestrogenic compounds show promise for PCa management.

Conclusions:

  • Estrogen pathways are critical targets for prostate cancer intervention.
  • Understanding estrogen's role offers new avenues for PCa prevention and treatment strategies.
  • Further research into estrogenic/antiestrogenic compounds could lead to novel therapies.

More Related Videos

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...