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Related Concept Videos

Bacteriophages of the Human Virome01:23

Bacteriophages of the Human Virome

Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...
DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the lytic replication...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Mycobacteriophage genome database.

Jerrine Joseph1, Vasanthi Rajendran, Sameer Hassan

  • 1Department of Bacteriology, Tuberculosis Research Centre (Indian Council of Medical Research), Mayor VR Ramanathan road, Chetput, Chennai - 600 031, India.

Bioinformation
|September 10, 2011
PubMed
Summary
This summary is machine-generated.

The Mycobacteriophage Genome Database (MGDB) consolidates 64 sequenced mycobacteriophage genomes and 6086 genes. This resource aids researchers by organizing and annotating mycobacteriophage protein classifications.

Keywords:
MySQLMycobacteriophagesPHPannotationdatabasegenome

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Area of Science:

  • Bioinformatics
  • Genomics
  • Microbiology

Background:

  • Mycobacteriophages are viruses that infect mycobacteria.
  • A comprehensive database for mycobacteriophage genomes is essential for research.
  • Existing data was fragmented across multiple sources.

Purpose of the Study:

  • To create a centralized repository for mycobacteriophage genomic data.
  • To provide annotated information for genes and proteins.
  • To facilitate classification and analysis of mycobacteriophage genomes.

Main Methods:

  • Compilation of data from public databases.
  • Manual curation and enrichment of information.
  • Development of a web interface for browsing and querying.
  • Classification of genes into families using the ACLAME database.

Main Results:

  • The Mycobacteriophage Genome Database (MGDB) Version 1.0 is established.
  • Contains 6086 genes from 64 completely sequenced mycobacteriophages.
  • Genes are classified into 72 families.
  • Web interface allows data exploration and functional annotation.

Conclusions:

  • MGDB provides a valuable, organized resource for mycobacteriophage research.
  • The database simplifies the study of mycobacteriophage protein classification.
  • Facilitates the description and analysis of new and existing genomes.