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Updated: May 29, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Interaction of the microbiome with the innate immune response in chronic wounds
Elizabeth A Grice1, Julia A Segre
1Epithelial Biology Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4442, USA. gricee@mail.nih.gov
Abstract:
Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and interactive role in impaired healing, especially in amplifying and perpetuating the host innate immune response. The development of molecular techniques to identify and quantify microbial organisms has revolutionized our view of the microbial world. These less-biased, high throughput methods greatly enable investigations regarding host-microbe interactions in the chronic wound environment. This review focuses on the mounting evidence implicating microbes and excessive inflammation in chronic wounds, as well as the challenges associated with understanding how microbes modulate wound healing and the innate immune response.
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