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Related Experiment Videos

Changes in gastrointestinal, pancreatic, biliary, and hepatic function with aging.

D F Altman1

  • 1School of Medicine, University of California, San Francisco.

Gastroenterology Clinics of North America
|June 1, 1990
PubMed
Summary

Understanding normal aging of the gastrointestinal, pancreatic, and hepatobiliary systems is challenging. While predictable changes occur, their functional significance in aging requires further investigation and validated animal models.

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Area of Science:

  • Gastroenterology
  • Gerontology
  • Hepatology
  • Pancreatology

Background:

  • Assessing normal aging in the gastrointestinal tract, pancreas, and hepatobiliary system is difficult due to challenges in identifying healthy elderly subjects.
  • Aging is associated with predictable alterations in gastric function, intestinal and pancreatic structure, colorectal motility, and liver characteristics.

Purpose of the Study:

  • To review the current understanding of age-related changes in the digestive system.
  • To highlight the variability in the functional impact of these aging-related modifications.
  • To identify areas for future research, including the need for validated animal models.

Main Methods:

  • Literature review and synthesis of existing research on aging and the gastrointestinal, pancreatic, and hepatobiliary systems.

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  • Analysis of data regarding changes in gastric secretion and emptying, intestinal and pancreatic morphology, colorectal motility, and hepatic mass and blood flow.

    • Main Results:

    • Identified predictable physiological changes in the gastrointestinal tract, pancreas, and hepatobiliary system with aging.
    • Highlighted the variable functional significance of these observed age-related changes.
    • Noted conflicting data in current research that necessitates further investigation.

    Conclusions:

    • Further research is essential to clarify the functional implications of aging on the digestive organs.
    • Validation of animal models is crucial for advancing the study of aging in these systems.
    • A clearer understanding of normal aging processes is needed to differentiate from age-related pathologies.