An aryl-phosphonate appended macrocyclic platform for lanthanide based bimodal imaging agents

Area of Science:

• Coordination Chemistry
• Biomedical Imaging
• Materials Science

Background:

• Bimodal probes combine multiple imaging modalities for enhanced diagnostic capabilities.
• Lanthanide complexes are promising for developing advanced imaging agents due to their unique photophysical and magnetic properties.

Purpose of the Study:

• To design and synthesize novel ligand systems for bimodal Magnetic Resonance Imaging (MRI) and luminescence probes.
• To evaluate the performance of the resulting lanthanide complexes as imaging agents.

Main Methods:

• Synthesis of four distinct ligand systems.
• Characterization of lanthanide complexes.
• Assessment of relaxivity and luminescence quantum yields.
• Evaluation of probe stability in competitive environments (model extracellular medium, cultured cells) and at higher magnetic fields.

Main Results:

• Successfully prepared four ligand systems tailored for bimodal probes.
• Lanthanide complexes exhibited high MRI relaxivity and luminescence quantum yields.
• These properties remained stable at higher magnetic fields and in biological mimic environments.

Conclusions:

• The developed ligand systems are well-suited for creating effective bimodal MRI and luminescence probes.
• The lanthanide complexes demonstrate robust performance, indicating their potential for in vitro and in vivo imaging applications.