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Updated: May 28, 2026
07:18
An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
Published on: October 11, 2022
Rickets.
1Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, M13 9WL, UK. zulf.mughal@cmft.nhs.uk
Current Osteoporosis Reports
|October 5, 2011
Summary
Nutritional rickets is a growing global concern, particularly among dark-skinned infants in developed nations. Factors like low vitamin D, reduced sun exposure, and genetics contribute to this preventable bone disorder.
Area of Science:
- Pediatrics
- Endocrinology
- Nutritional Science
Background:
- Rickets is a bone disorder in growing children characterized by impaired growth plate mineralization.
- Nutritional rickets remains a significant global health issue, with a resurgence in certain populations.
- Key contributing factors include latitude, reduced ultraviolet B radiation exposure, maternal vitamin D deficiency, and inadequate supplementation during breastfeeding.
Purpose of the Study:
- To review the causes and contributing factors to the resurgence of nutritional rickets.
- To discuss the role of fibroblast growth factor 23 (FGF23) in hypophosphatemic rickets.
Main Methods:
- Literature review of studies on rickets, vitamin D deficiency, and FGF23.
- Analysis of epidemiological data and risk factors for rickets.
- Review of the pathophysiology of FGF23 in mineral metabolism.
Main Results:
- Nutritional rickets is prevalent in dark-skinned infants in developed countries due to various environmental and maternal factors.
- Fibroblast growth factor 23 (FGF23) plays a crucial role in regulating serum phosphate and vitamin D levels.
- Increased FGF23 synthesis or reduced breakdown leads to hypophosphatemic rickets.
Conclusions:
- Rickets is a multifactorial disease influenced by vitamin D status, sun exposure, and genetic factors.
- FGF23 is a key mediator in phosphate homeostasis and its dysregulation causes specific forms of rickets.
- Public health strategies addressing vitamin D deficiency and promoting safe sun exposure are essential for preventing rickets.
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