Related Experiment Video

Updated: May 28, 2026

Undecalcified Bone Preparation for Histology, Histomorphometry and Fluorochrome Analysis
07:29

Undecalcified Bone Preparation for Histology, Histomorphometry and Fluorochrome Analysis

Published on: January 8, 2010

Informed choices for challenging specimens when choosing methacrylate resin systems for histology

Sim K Singhrao1, Ken Nicholson, Stjohn Crean

  • 1Oral and Dental Sciences Research Group, School of Postgraduate Medical and Dental Education, University of Central Lancashire, Preston PR1 2HE, United Kingdom. SKSinghrao@uclan.ac.uk

Microscopy Research and Technique
|October 15, 2011
PubMed
Summary

Histopathology techniques for challenging specimens like bone and teeth have advanced. Impregnating tissues with methacrylate resins improves cellular structure preservation and reduces fractures during processing.

More Related Videos

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography07:41

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography

Published on: October 17, 2018

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging09:31

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

Related Concept Videos

Fixation and Sectioning01:03

Fixation and Sectioning

Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
Preparation of Samples for Electron Microscopy01:20

Preparation of Samples for Electron Microscopy

To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...