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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

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Related Experiment Video

Updated: May 28, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Teriparitide update.

Stuart L Silverman1, Keaton Nasser

  • 1Cedars-Sinai Bone Center of Excellence, 8641 Wilshire Boulevard, Suite 301, Beverly Hills, CA 90211, USA. stuarts@omcresearch.org

Rheumatic Diseases Clinics of North America
|October 26, 2011
PubMed
Summary
This summary is machine-generated.

Teriparitide (TPD) is an anabolic agent that stimulates bone formation and reduces fracture risk. Ongoing research explores its expanded applications beyond glucocorticoid-induced osteoporosis, including fracture healing and pain management.

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Published on: December 10, 2010

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Last Updated: May 28, 2026

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Teriparitide (TPD) is a potent anabolic agent stimulating bone formation.
  • TPD is proven to reduce vertebral and nonvertebral fracture risks.
  • TPD is approved for treating glucocorticoid-induced osteoporosis.

Purpose of the Study:

  • To explore novel applications of Teriparitide (TPD) in bone health.
  • To address remaining questions regarding TPD's therapeutic potential.
  • To investigate TPD's role in fracture healing and osteoporotic back pain.

Main Methods:

  • Review of existing clinical studies and research on Teriparitide.
  • Analysis of TPD's anabolic mechanisms and clinical outcomes.
  • Identification of knowledge gaps in TPD's therapeutic use.

Main Results:

  • TPD demonstrates significant bone-forming activity.
  • TPD effectively reduces fracture incidence.
  • Emerging research suggests potential in fracture healing and pain relief.

Conclusions:

  • Teriparitide (TPD) offers a promising anabolic approach for osteoporosis management.
  • Further research is warranted to optimize TPD's use in combination, sequential, and follow-up therapies.
  • TPD's role in fracture healing and osteoporotic pain requires additional investigation.