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Updated: May 28, 2026
11:42
Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides
Marco Bartoloni1, Rameshwar U Kadam, Julian Schwartz
1Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland.
Chemical Communications (Cambridge, England)
|October 28, 2011
Abstract:
Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short α-helical peptides.
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