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Familial vocal cord dysfunction associated with digital anomalies.
D B Hawkins1, M Liu-Shindo, E J Kahlstrom
1Department of Otolaryngology, University of Southern California Medical Center.
The Laryngoscope
|September 1, 1990
Summary
Familial vocal cord dysfunction, a rare condition, was observed in identical twins with congenital abductor vocal cord paresis and finger deformities. This genetic disorder impacts breathing and vocal cord function across multiple family members.
Area of Science:
- Genetics
- Otolaryngology
- Pediatrics
Background:
- Familial vocal cord dysfunction is exceptionally rare, with limited documented cases.
- Congenital laryngeal abnormalities can present with significant respiratory distress in infants.
Observation:
- Identical male twins presented with congenital bilateral abductor vocal cord paresis and associated digital abnormalities.
- Progression of vocal cord paresis to paralysis necessitated tracheotomy, followed by a phase of synkinesis.
Findings:
- The condition demonstrated familial inheritance, with affected siblings and relatives exhibiting stridor, vocal cord paralysis, and finger deformities.
- A distinct pattern of vocal cord dysfunction and digital anomalies suggests a potential genetic linkage.
Implications:
- This case highlights a rare inherited disorder affecting the larynx and digits.
- Further research into the genetic basis of familial vocal cord dysfunction is warranted.
- Understanding this condition can improve diagnosis and management of similar congenital respiratory and developmental issues.