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Updated: May 28, 2026

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
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Implantable polyimide cable for multichannel high-data-rate neural recording microsystems.

Tao Sun1, Woo-Tae Park, Min-Yuan Cheng

  • 1Institute of Microelectronics, Agency for Science, Technology and Research, Singapore. sunt@ime.a-star.edu.sg

IEEE Transactions on Bio-Medical Engineering
|November 2, 2011
PubMed
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A new flexible polyimide (PI) cable minimizes brain injury from micromotion. This implantable neural interface cable effectively transmits data and power while maintaining biocompatibility.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Minimizing postimplantation injury from brain micromotion is critical for neural interface devices.
  • Flexible cables are needed for reliable data and power transmission between intracranial and extracranial components.

Purpose of the Study:

  • To design and microfabricate a flexible multichannel polyimide (PI) cable for neural probes.
  • To investigate the surface characteristics, electrical properties, and cytocompatibility of the fabricated PI cable.

Main Methods:

  • Scanning electron microscopy (SEM) and atomic force microscopy (AFM) for surface analysis.
  • Water vapor transmission rate (WVTR) and wettability measurements.
  • Scattering parameter (S-parameter) measurements for electrical properties.

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Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
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Last Updated: May 28, 2026

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
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High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode
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High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode

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06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

  • MTT assay and live/dead staining for cytocompatibility evaluation.

    • Main Results:

    • Surface roughening occurred due to ion etching, increasing wettability and water absorption but not significantly affecting WVTR.
    • Electrical properties, including insertion loss, isolation, and data transmission capacity, were within acceptable ranges.
    • PI cable demonstrated no acute cytotoxicity and good cytocompatibility, comparable to blank PI foils.

    Conclusions:

    • The developed flexible PI cable is suitable for neural interfaces, offering reliable data/power transmission.
    • The microfabrication process yields a biocompatible material that minimizes risks associated with brain micromotion.