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Biologic response modifiers: relevance & repercussions.
Romesh Khardori1, Nancy Misri Khardori
1Division of Endocrinology & Metabolism, Eastern Virginia Medical School, Norfolk, VA 23507, USA. rkhardori@gmail.com
Infectious Disease Clinics of North America
|November 8, 2011
Summary
Biologic response modifiers (BRMs) are natural or manufactured substances used in targeted therapy. While promising for advanced cancers, caution is advised for chronic diseases due to potential harm outweighing benefits.
Area of Science:
- Immunology and Pharmacology
- Biotechnology
Background:
- Biologic response modifiers (BRMs) are endogenous or synthetically produced compounds.
- BRMs function as targeted therapies with significant clinical potential.
Purpose of the Study:
- To explore the therapeutic applications of BRMs.
- To evaluate the risk-benefit profile of BRMs in different disease contexts.
Main Methods:
- Literature review of BRM applications.
- Analysis of BRM efficacy and safety data.
Main Results:
- BRMs show promise in treating advanced cancers where conventional therapies are ineffective.
- Potential risks associated with BRM use in chronic indolent diseases were identified.
Conclusions:
- BRMs represent a valuable therapeutic option for refractory cancers.
- Careful consideration of the risk-benefit ratio is crucial when prescribing BRMs for chronic conditions.
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