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Updated: May 27, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Biologic response modifiers: relevance & repercussions.

Romesh Khardori¹, Nancy Misri Khardori

¹Division of Endocrinology & Metabolism, Eastern Virginia Medical School, Norfolk, VA 23507, USA. rkhardori@gmail.com

Infectious Disease Clinics of North America

|November 8, 2011

Summary

Biologic response modifiers (BRMs) are natural or manufactured substances used in targeted therapy. While promising for advanced cancers, caution is advised for chronic diseases due to potential harm outweighing benefits.

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Last Updated: May 27, 2026

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In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

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Published on: May 4, 2017

Area of Science:

Immunology and Pharmacology
Biotechnology

Background:

Biologic response modifiers (BRMs) are endogenous or synthetically produced compounds.
BRMs function as targeted therapies with significant clinical potential.

Purpose of the Study:

To explore the therapeutic applications of BRMs.
To evaluate the risk-benefit profile of BRMs in different disease contexts.

Main Methods:

Literature review of BRM applications.
Analysis of BRM efficacy and safety data.

Main Results:

BRMs show promise in treating advanced cancers where conventional therapies are ineffective.
Potential risks associated with BRM use in chronic indolent diseases were identified.

Conclusions:

BRMs represent a valuable therapeutic option for refractory cancers.
Careful consideration of the risk-benefit ratio is crucial when prescribing BRMs for chronic conditions.