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10:04
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
[Nontuberculous mycobacterial lung infections]
Christian Chuard1, Véronique Erard
1Clinique de médecine et Unité de prévention et contrôle de l'infection, Hôpital fribourgeois, 1708 Fribourg. chuardc@h-fr.ch
Revue Medicale Suisse
|November 22, 2011
Summary
Nontuberculous mycobacterial (NTM) infections, often causing pulmonary disease, are rising. Diagnosis requires clinical, radiological, and microbiological evidence, with treatment being lengthy and not always successful.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Microbiology
Context:
- Increasing incidence of nontuberculous mycobacterial (NTM) infections, primarily affecting the lungs.
- Environmental contamination is the source for both immunocompetent and immunocompromised patients.
- Limited number of pathogenic mycobacteria species despite numerous types.
Purpose:
- To outline the diagnostic criteria and challenges for pulmonary NTM infections.
- To describe common clinical and radiological presentations.
- To review current treatment strategies and their limitations.
Summary:
- Diagnosis relies on clinical presentation, imaging, and microbiological confirmation (culture, PCR) often requiring multiple samples.
- Typical presentations include tuberculosis-like disease and lung nodules with bronchiectasis.
- Treatment involves multiple antimicrobials for extended durations (over a year) with variable success rates.
Impact:
- Highlights the growing public health concern of NTM pulmonary disease.
- Emphasizes the need for accurate and timely diagnosis.
- Underscores the challenges in effectively treating these persistent infections.
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