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A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

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Pterostilbene and cancer: current review.

Denise McCormack¹, David McFadden

¹Department of Surgery, Danbury Hospital, Danbury, Connecticut 06810, USA. Denise.McCormack@wcthealthnetwork.org

The Journal of Surgical Research

|November 22, 2011

Summary

Pterostilbene, an antioxidant from blueberries, shows promise as an anticancer agent by inhibiting cancer growth and metastasis in preclinical studies. Its higher bioavailability and antioxidant effects warrant further investigation into human pharmacological mechanisms.

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Area of Science:

Nutritional Biochemistry
Pharmacology
Oncology

Background:

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally occurring antioxidant found in blueberries.
It possesses antineoplastic properties suggesting potential as an anticancer agent.
Preliminary data indicates superior bioavailability compared to other stilbenes.

Purpose of the Study:

To comprehensively review the antineoplastic mechanisms of pterostilbene.
To summarize preclinical findings on pterostilbene's anticancer effects.
To highlight recent advancements in pterostilbene research.

Main Methods:

Review of in vitro studies examining pterostilbene's effects on cancer cell lines.
Analysis of in vivo studies investigating pterostilbene's impact on tumorigenesis and metastasis.
Evaluation of preclinical data on pterostilbene's antioxidant capacity and bioavailability.

Main Results:

In vitro: Pterostilbene inhibits cancer cell cycle progression, induces apoptosis, and suppresses metastasis.
In vivo: Pterostilbene demonstrates inhibition of tumorigenesis and metastasis with minimal toxicity.
Pterostilbene enhances antioxidant capacity in cancer cells, potentially contributing to its anticarcinogenic function.

Conclusions:

Pterostilbene exhibits significant antineoplastic potential through multiple mechanisms.
Its favorable bioavailability and antioxidant properties make it a promising dietary compound for cancer research.
Further investigation into the pharmacological mechanisms and human effects of pterostilbene is warranted.