[Meta-analysis of pharmacological therapy with acamprosate, naltrexone, and disulfiram--a systematic review]
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Updated: May 27, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Igor Petrov1, Jesper Krogh, Merete Nordentoft
1Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, Blegdamsvej 3, 2200 København N, Denmark. mail@petrov.dk
Abstract:
The meta-analysis is based on 16 randomized controlled trials of acamprosate, 18 of naltrexone and 7 of disulfiram. Acamprosate and naltrexone were 52% (RR = 1.52; 95% confidence interval (CI): 1.35-1,72) and 27% (RR = 1.27; 95% CI: 1,06-1,52) better than placebo when it came to supporting continuous abstinence. Acamprosate increased the total number of abstinence days with 14% (MD = 14.02; 95% CI: 9.57-18.47). Disulfiram appeared to be effective only when the intake was supervised. Based on the amount of scientific evidence, acamprosate and naltrexone therapy should be increased in clinical practice in the treatment of alcoholism.
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