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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
Design concepts and strategies for tissue engineering scaffolds
1Fiber and Polymer Science, Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC 27695-8301, USA.
Biotechnology and Applied Biochemistry
|December 17, 2011
Summary
This review details tissue engineering scaffolds, focusing on design strategies like mimicking the extracellular matrix and ensuring vascularization for viable tissue regeneration. Key parameters and characteristics are explored for scaffold development and evaluation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Tissue engineering aims to create functional tissues using cells, scaffolds, and culture environments.
- Specific requirements for these components vary significantly with cell type and organ application.
- General design principles for tissue engineering scaffolds are crucial for successful fabrication.
Purpose of the Study:
- To review key concepts, parameters, and characteristics for tissue engineering scaffold development.
- To explore various design strategies for optimizing scaffold performance.
- To address the critical challenge of vascularization in engineered tissues.
Main Methods:
- Review of existing literature on tissue engineering scaffold design.
- Discussion of strategies including extracellular matrix mimicry, mass transport considerations, structural architecture, mechanical integrity, surface modification for cell signaling, and material selection for bioresorption.
- Analysis of vascularization challenges in three-dimensional tissue constructs.
Main Results:
- Identified general requirements for designing and fabricating tissue engineering scaffolds.
- Presented diverse design strategies to enhance scaffold functionality.
- Highlighted the necessity of vascularization for the viability of thick engineered tissues.
Conclusions:
- Scaffold design must consider specific cell types and organ applications.
- Optimizing scaffolds involves mimicking natural structures, ensuring transport, mechanical support, and appropriate degradation.
- Achieving adequate vascularization remains a primary challenge for complex tissue engineering.
