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Related Concept Videos

Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

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Related Experiment Video

Updated: May 26, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Histone methylation makes its mark on longevity.

Shuo Han1, Anne Brunet

  • 1Department of Genetics, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA.

Trends in Cell Biology
|December 20, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetic factors, like histone methylation, influence how long organisms live. Targeting these chromatin modifications offers potential for extending lifespan and healthspan.

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Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae

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Related Experiment Videos

Last Updated: May 26, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae
11:06

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae

Published on: December 29, 2017

Area of Science:

  • Genetics and Epigenetics
  • Molecular Biology
  • Aging Research

Background:

  • Organism lifespan is influenced by factors beyond genetics.
  • Epigenetic modifications, specifically histone methylation, are emerging as key regulators of longevity.
  • The reversible nature of these epigenetic changes suggests therapeutic potential.

Purpose of the Study:

  • To review the epigenetic regulation of lifespan across various model organisms.
  • To focus on the role of chromatin regulators in longevity.
  • To examine the impact of specific epigenetic marks, H3K4me3 and H3K27me3, on lifespan.

Main Methods:

  • Literature review of studies on epigenetic regulation of lifespan.
  • Analysis of chromatin modification mechanisms affecting longevity.
  • Focus on histone methylation and its regulators in model organisms.

Main Results:

  • Epigenetic factors, particularly histone methylation, significantly impact organism lifespan.
  • Chromatin regulators play a crucial role in mediating these lifespan effects.
  • Specific epigenetic marks like H3K4me3 and H3K27me3 are implicated in longevity pathways.

Conclusions:

  • Epigenetic regulation is a critical determinant of lifespan.
  • Targeting chromatin regulators offers a promising therapeutic strategy for extending lifespan and healthspan.
  • Further research into H3K4me3 and H3K27me3 regulation could unlock new longevity interventions.