Peptoids at the 7th Summit: toward macromolecular systems engineering

Area of Science:

• Foldamer science and technology
• Supramolecular assembly
• Nanotechnology

Background:

• Peptoids offer facile synthesis of diverse peptide-like oligomers.
• The 7th Peptoid Summit highlighted advancements and future prospects in peptoid science.
• Rapid progress in DNA and protein engineering is enabling complex self-assembled nanosystems.

Framework:

• Comparative analysis reveals peptoids' suitability for self-assembled nanosystems.
• Physical parallels between peptoids and proteins suggest the need for specialized design software.
• Novel side-chain functionalities in peptoids can exploit unique binding interactions.

Implementation:

• Peptoid engineering requires specialized software, similar to protein engineering.
• Crystal engineering principles can inform peptoid design for novel binding interactions.
• Integrating peptoid foldamer technology into existing nanotechnologies is crucial.

Implications:

• Peptoids can contribute to the convergence of DNA, protein, and inorganic nanotechnologies.
• This convergence facilitates the design and fabrication of atomically precise nanosystems.
• Peptoid-based foldamer technologies expand the scope of macromolecular nanosystems engineering.