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Updated: May 26, 2026
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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Are CT angiography source images accurate for evaluating infarct volume?
Masaki Watanabe1, Adnan I Qureshi
1Zeenat Qureshi Stroke Research Center, University of Minnesota, Minneapolis, MN 55455, USA. masakiwatanabe3@gmail.com
Summary
CT angiography source images (CTA-SI) show promise for detecting stroke infarct cores. However, standardized protocols are crucial, as fast protocols may overestimate infarct size due to poor collateral circulation.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Noncontrast computed tomography (NCCT) is the standard for thrombolysis eligibility.
- CT angiography (CTA) visualizes cranio-cervical vessels and occlusion.
- CTA source images (CTA-SI) assess cerebral blood volume and detect infarct cores.
Purpose of the Study:
- To evaluate the reliability of CTA-SI in assessing the infarct core in acute stroke.
- To compare the accuracy of different CTA acquisition protocols for infarct core measurement.
Main Methods:
- Review of existing literature on CT angiography source images in acute stroke.
- Analysis of CTA-SI performance in detecting infarct core compared to NCCT.
- Investigation of the impact of acquisition protocols (fast vs. standardized) on infarct core estimation.
Main Results:
- CTA-SI demonstrates higher sensitivity than NCCT in detecting infarct core.
- Fast CTA-SI protocols may overestimate infarct core size, particularly with poor collaterals.
- Standardized CTA-SI protocols show potential as predictors of final infarct extension.
Conclusions:
- CTA-SI is a valuable tool for evaluating the infarct core in acute stroke.
- Standardized CTA-SI protocols are recommended for accurate infarct core assessment.
- Further research is needed to refine CTA-SI measures for reliable infarct core evaluation.
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