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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 25, 2026

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
07:42

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Future perspectives on brain metastasis management.

Edward A Monaco Iii, Phillip V Parry, Ramesh Grandhi

    Progress in Neurological Surgery
    |January 13, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Stereotactic radiosurgery offers an effective, minimally invasive treatment for brain metastases, shifting focus from whole-brain radiation. This approach improves outcomes for patients with intracranial tumors.

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    Related Experiment Videos

    Last Updated: May 25, 2026

    Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
    07:42

    Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

    Published on: January 16, 2026

    Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
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    Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

    Published on: June 7, 2020

    Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
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    Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

    Published on: February 8, 2017

    Area of Science:

    • Neurology
    • Oncology
    • Radiation Oncology

    Background:

    • Brain metastases are the most common intracranial tumors.
    • Traditional treatments like surgery and whole-brain radiation therapy have limitations in efficacy and toxicity.
    • Advances in systemic cancer treatment necessitate improved brain metastasis management.

    Purpose of the Study:

    • To review the evolution of brain metastasis treatment.
    • To discuss the changing role of whole-brain radiation therapy.
    • To highlight the increasing importance of stereotactic radiosurgery.

    Main Methods:

    • Review of historical and current treatment modalities for brain metastases.
    • Analysis of the impact of stereotactic radiosurgery on treatment paradigms.
    • Discussion of radiosurgery in conjunction with surgery and salvage options.

    Main Results:

    • Stereotactic radiosurgery has emerged as a paradigm shift in treating brain metastases.
    • Radiosurgery is an efficacious, minimally invasive, and highly selective treatment option.
    • The role of reflexive whole-brain radiation is diminishing.

    Conclusions:

    • Stereotactic radiosurgery is a crucial upfront treatment modality for brain metastases.
    • It complements surgical interventions and salvage radiosurgery.
    • Continued advancements in brain metastasis treatment are essential.