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Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors

Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors

Published on: May 31, 2012

A multifunctional pipette.

Alar Ainla¹, Gavin D M Jeffries, Ralf Brune

¹Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296, Göteborg, Sweden.

|January 19, 2012

Summary

This summary is machine-generated.

This study introduces an optimized open-volume microfluidic tool for precise cell manipulation. This non-contact hydrodynamically confined microflow pipette overcomes limitations of traditional closed microchannels.

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Area of Science:

Biotechnology
Microfluidics
Cell Biology

Background:

Microfluidics enables cellular and sub-cellular analysis but often uses restrictive closed channels.
Existing microfluidic devices limit sample preparation and experimental flexibility.

Purpose of the Study:

To develop an optimized non-contact open-volume microfluidic tool.
To overcome limitations associated with closed microchannel systems.
To provide a multifunctional handling and dispensing solution.

Main Methods:

Utilized a hydrodynamically confined microflow pipette design.
Optimized geometries for optical microscopy compatibility.
Integrated solution reservoirs to minimize reagent use and contamination.
Characterized device performance using epifluorescence and total internal reflection fluorescence (TIRF) microscopy.

Main Results:

Achieved rapid solution exchange times.
~200 ms exchange time at a 100 nm distance to the surface.
~130 ms exchange time at a 30 μm distance to the surface.

Conclusions:

The developed open-volume microfluidic tool offers enhanced flexibility for biological sample manipulation.
The design minimizes reagent consumption and contamination risks.
The tool is suitable for high-resolution optical microscopy applications.